Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 4/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7543546 | 0.83 | ALOX15 (0.35) | ALDH1A1PARP10 | |
| SCHEMBL7540966 | 0.83 | CCR4 (0.36) | POLBHPGDSCCR4EDNRAALDH1A1 | |
| SCHEMBL15233567 | 0.79 | CCR4 (0.38) | CCR4EDNRAPIK3CAALDH1A1 | |
| SCHEMBL7542068 | 0.79 | ALOX5 (0.39) | POLBALDH1A1CDC7DBF4 | |
| SCHEMBL29212506 | 0.78 | NNMT (0.37) | POLBNNMTSIRT6HPGDSMKNK1 | |
| SCHEMBL3170311 | 0.77 | POLB (0.42) | POLBNNMTSIRT6HPGDSMKNK1 | |
| SCHEMBL7544495 | 0.76 | CDC7 (0.39) | POLBNNMTSIRT6MKNK1MKNK2 | |
| SCHEMBL7542109 | 0.75 | MAPT (0.44) | ALDH1A1PARP1 | |
| SCHEMBL29243306 | 0.75 | CCR4 (0.39) | POLBNNMTSIRT6CCR4EDNRA | |
| SCHEMBL7542243 | 0.71 | POLB (0.40) | POLBSIRT6CCR4EDNRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | claimed |
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | disclosed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | disclosed |