SCHEMBL7544201

SCHEMBL7544201

CNCCCOCc1ccc(O)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TMEM97 Q5BJF2 1/20 0.55
SIGMAR1 Q99720 1/20 0.55
HTR1B P28222 1/20 0.43
SCN8A Q9UQD0 1/20 0.42
ESR1 P03372 2/20 0.41
ESR2 Q92731 1/20 0.41
IDO1 P14902 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
ADRB2 P07550 1/20 0.40
ADRB1 P08588 1/20 0.40
ADRB3 P13945 1/20 0.40
HRH1 P35367 1/20 0.39
THPO P40225 2/20 0.39
HIF1A Q16665 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39
HTR1A P08908 1/20 0.39
BLM P54132 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6041506 0.83 HTR1B (0.58) TMEM97SIGMAR1HTR1BL3MBTL1HRH1
SCHEMBL7552826 0.82 L3MBTL1 (0.56) HTR1BSCN8AIDO1L3MBTL1TDP1
SCHEMBL7547865 0.80 ADRB2 (0.45) HTR1BADRB2ADRB1ADRB3HRH1
SCHEMBL1839898 0.79 LTA4H (0.55) ESR1ESR2IDO1L3MBTL1ADRB3
SCHEMBL17412612 0.78 L3MBTL1 (0.60) TMEM97SIGMAR1HTR1BL3MBTL1HRH1
SCHEMBL1833481 0.77 NR5A1 (0.58) ESR1IDO1L3MBTL1ADRB3HIF1A
SCHEMBL27360791 0.76 SIGMAR1 (0.59) TMEM97SIGMAR1HTR1BL3MBTL1ADRB2
SCHEMBL3817061 0.76 SIGMAR1 (0.59) TMEM97SIGMAR1HTR1BL3MBTL1ADRB2
SCHEMBL4636049 0.76 SIGMAR1 (0.76) TMEM97SIGMAR1ESR1ESR2L3MBTL1
SCHEMBL13592287 0.76 L3MBTL1 (0.61) IDO1L3MBTL1TDP1KDM4ECALM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed