Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | DHFR | P00374 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039560 | 0.86 | TSHR (0.67) | SMN1; SMN2TDP1DHFRTSHRAKR1C2 | |
| SCHEMBL4071822 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2TDP1DHFRTSHRAKR1C2 | |
| SCHEMBL7899812 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2TDP1DHFRTSHRAKR1C2 | |
| SCHEMBL209632 | 0.82 | DHFR (0.66) | SMN1; SMN2TDP1DHFRTSHRAKR1C2 | |
| SCHEMBL19629792 | 0.81 | F2 (0.50) | TDP1TSHRF2PRSS1PRSS2 | |
| SCHEMBL19627411 | 0.80 | ALDH1A1 (0.68) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19627396 | 0.80 | F2 (0.49) | TSHRF2PRSS1PRSS2PRSS3 | |
| SCHEMBL5931251 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2TDP1DHFRTSHRPKM | |
| SCHEMBL1764031 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TSHRF2PRSS1PRSS2 | |
| SCHEMBL7541831 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2TDP1DHFRTSHRAKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334894-A1 | Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof | ENANTA PHARMACEUTICALS, INC. | 2017-11-23 | — | — | US | disclosed |
| US-20170333399-A1 | Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof | ENANTA PHARMACEUTICALS, INC. | 2017-11-23 | — | — | US | disclosed |
| US-20020094993-A1 | Compositions for repelling crawling insects | S.C. JOHNSON & SON, INC. | 2002-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334894-A1 | Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof | SLC10A1, FXR1, NR1H4 | SMN1; SMN2 4675/4885TDP1 3945/4885DHFR 1038/4885 |
| US-20170333399-A1 | Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof | SLC10A1, FXR1, SLC10A2 | SMN1; SMN2 4664/4885TDP1 3899/4885DHFR 1016/4885 |
| US-20020094993-A1 | Compositions for repelling crawling insects | ACHE, DDT, GAP43 | SMN1; SMN2 2971/4885TDP1 3063/4885DHFR 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.