Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.42 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TK2 | O00142 | 4/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554990 | 0.90 | TK1 (0.47) | TK1TYMPMAPK1HPGDCYP1A2 | |
| SCHEMBL11723021 | 0.85 | SMN1; SMN2 (0.44) | TK1TYMPMAPK1HPGD | |
| SCHEMBL4118603 | 0.81 | MAPK1 (0.57) | TK1TYMPMAPK1HPGDTK2 | |
| SCHEMBL28985700 | 0.79 | LMNA (0.42) | TK1TYMPMAPK1GAACYP2C9 | |
| SCHEMBL7549198 | 0.77 | TYMP (0.43) | TK1TYMPMAPK1HPGD | |
| SCHEMBL10105030 | 0.75 | CRBN (0.39) | TK1MAPK1 | |
| SCHEMBL28985696 | 0.75 | TK1 (0.37) | TK1TYMPMAPK1HPGDKMT2A | |
| SCHEMBL7546248 | 0.73 | HPGD (0.72) | TK1MAPK1HPGD | |
| SCHEMBL7679806 | 0.70 | CYP2C19 (0.40) | TYMPHPGDCYP1A2CYP2C19GAA | |
| SCHEMBL13261412 | 0.70 | TK1 (0.62) | TK1TYMPMAPK1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165554-A1 | NEW ENDOTHELIN CONVERTING ENZYME INHIBITORS, THEIR PRODUCTION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061579-A1 | NEW ENDOTHELIN CONVERTING ENZYME INHIBITORS, THEIR PRODUCTION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-19 | — | — | WO | disclosed |