Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7546349 | 0.95 | SIGMAR1 (0.48) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| SCHEMBL7550443 | 0.81 | SIGMAR1 (0.54) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9602476 | 0.78 | DRD3 (0.51) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL7541857 | 0.76 | MAPT (0.61) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7549103 | 0.75 | HTR1A (0.63) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9601482 | 0.74 | SIGMAR1 (0.48) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9601471 | 0.74 | SIGMAR1 (0.48) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| SCHEMBL8878898 | 0.73 | DRD2 (0.67) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL7544875 | 0.72 | DRD2 (0.65) | SIGMAR1DRD4HTR1ADRD2ADRA2C | |
| SCHEMBL8037087 | 0.71 | MAPK1 (0.58) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652867-B1 | NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES | BIOVITRUM AB (SE) | 2002-06-12 | — | — | EP | disclosed |
| US-6326371-B1 | ANTISEROTININE AGENTS | PHARMACIA AKTIEBOLAG (SE) | 2001-12-04 | — | — | US | disclosed |
| US-5652240-A | PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | PHARMACIA AKTIEBOLAG (SE) | 1997-07-29 | — | — | US | disclosed |
| EP-0652867-A1 | NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES | Pharmacia & Upjohn Aktiebolag (SE) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994003430-A1 | NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES | KABI PHARMACIA AB (SE) | 1994-02-17 | — | — | WO | disclosed |