Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7546349 | 0.83 | SIGMAR1 (0.48) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL7549103 | 0.82 | HTR1A (0.63) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL7541857 | 0.81 | MAPT (0.61) | SIGMAR1 | |
| SCHEMBL7547673 | 0.81 | SIGMAR1 (0.46) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL8878898 | 0.80 | DRD2 (0.67) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL9601882 | 0.80 | SIGMAR1 (0.56) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL7544875 | 0.79 | DRD2 (0.65) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL11180176 | 0.74 | SIGMAR1 (0.70) | SIGMAR1HTR1ADRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL11191151 | 0.73 | SIGMAR1 (0.67) | SIGMAR1 | |
| SCHEMBL11175427 | 0.73 | SIGMAR1 (0.67) | SIGMAR1HTR1ADRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652867-B1 | NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES | BIOVITRUM AB (SE) | 2002-06-12 | — | — | EP | disclosed |
| US-6326371-B1 | ANTISEROTININE AGENTS | PHARMACIA AKTIEBOLAG (SE) | 2001-12-04 | — | — | US | disclosed |
| US-5652240-A | PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | PHARMACIA AKTIEBOLAG (SE) | 1997-07-29 | — | — | US | disclosed |
| EP-0652867-A1 | NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES | Pharmacia & Upjohn Aktiebolag (SE) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994003430-A1 | NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES | KABI PHARMACIA AB (SE) | 1994-02-17 | — | — | WO | disclosed |