Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329175 | 0.92 | EDNRA (0.44) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7494883 | 0.85 | EDNRA (0.46) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8785947 | 0.79 | P2RX7 (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2APLNR | |
| SCHEMBL8431636 | 0.78 | ALDH1A1 (0.40) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6580198 | 0.78 | EDNRA (0.44) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6580025 | 0.77 | KDM4E (0.36) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6579920 | 0.76 | EDNRA (0.46) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7501396 | 0.76 | EDNRA (0.45) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6580278 | 0.75 | EDNRA (0.45) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7498870 | 0.74 | EDNRA (0.59) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | claimed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |