Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.74 |
| ▸ | FLT1 | P17948 | 5/20 | 0.66 |
| ▸ | FLT4 | P35916 | 5/20 | 0.66 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990489 | 0.94 | KDR (0.75) | KDRFLT1FLT4CYP2A6MAPK14 | |
| SCHEMBL7990540 | 0.91 | KDR (0.75) | KDRFLT1FLT4CYP2A6MAPK14 | |
| SCHEMBL7548593 | 0.87 | KDR (0.57) | KDRFLT1FLT4MAPK14GSK3B | |
| SCHEMBL7549006 | 0.87 | KDR (0.75) | KDRFLT1FLT4CYP2A6HTR7 | |
| SCHEMBL7557708 | 0.87 | KDR (0.56) | KDRFLT1FLT4CYP2A6HTR7 | |
| SCHEMBL7549908 | 0.85 | KDR (1.00) | KDRFLT1FLT4CYP2A6HTR7 | |
| SCHEMBL7556531 | 0.85 | KDR (1.00) | KDRFLT1FLT4CYP2A6HTR7 | |
| SCHEMBL7555532 | 0.84 | KDR (0.52) | KDRFLT1FLT4MAPK14GSK3B | |
| SCHEMBL7988086 | 0.83 | KDR (0.51) | KDRFLT1FLT4MAPK14DRD2 | |
| SCHEMBL7551698 | 0.82 | KDR (0.73) | KDRFLT1FLT4CYP2A6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |