Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | HPN | P05981 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550086 | 0.90 | L3MBTL1 (0.32) | L3MBTL1ROCK2HPNMAPTRECQL | |
| SCHEMBL9078667 | 0.87 | L3MBTL1 (0.31) | L3MBTL1ROCK2HPN | |
| Hydrochloric Acid SCHEMBL7554193 | 0.85 | GRIN1 (0.32) | GRIN1MDM2 | |
| SCHEMBL7548916 | 0.81 | GRIN1 (0.32) | L3MBTL1ROCK2GRIN1MAPT | |
| SCHEMBL9079933 | 0.78 | L3MBTL1 (0.31) | L3MBTL1HPN | |
| SCHEMBL7550462 | 0.76 | MTNR1A (0.32) | L3MBTL1ROCK2 | |
| SCHEMBL7550571 | 0.76 | GRIN1 (0.33) | GRIN1MDM2 | |
| SCHEMBL7548912 | 0.75 | NR1I3 (0.31) | — | |
| SCHEMBL7550093 | 0.73 | PPARD (0.33) | L3MBTL1ROCK2GRIN1MAPT | |
| SCHEMBL7653673 | 0.72 | ROCK2 (0.31) | L3MBTL1ROCK2GRIN1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |