SCHEMBL9079933

SCHEMBL9079933

COC(=O)c1[nH]c2cc(Br)cc3c2c1C(C(C(N)=O)c1ccc(CNC(=O)OC(C)(C)C)cc1C(=O)O)CC3

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.31
IGF1R P08069 1/20 0.31
FPR3 P25089 1/20 0.30
FPR2 P25090 1/20 0.30
HPN P05981 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9078667 0.92 L3MBTL1 (0.31) L3MBTL1HPN
SCHEMBL7547784 0.81 MTNR1A (0.34) L3MBTL1IGF1RFPR3FPR2
SCHEMBL7548907 0.78 L3MBTL1 (0.32) L3MBTL1HPN
SCHEMBL7554008 0.78 FPR3 (0.36) L3MBTL1IGF1RFPR3FPR2
SCHEMBL7550086 0.77 L3MBTL1 (0.32) L3MBTL1IGF1RHPN
SCHEMBL7547793 0.73 AAK1 (0.35)
SCHEMBL7548909 0.73 MTNR1A (0.32) L3MBTL1FPR3FPR2
SCHEMBL7548639 0.72 MTNR1A (0.32) L3MBTL1
SCHEMBL7550440 0.72 MTNR1A (0.32) FPR3FPR2
SCHEMBL7551122 0.72 MTNR1A (0.32) L3MBTL1FPR3FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5496843-A Tricyclic indole-2-carboxylic acid derivatives SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1996-03-05 US disclosed