Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053843 | 0.84 | CAMKK2 (0.63) | PIM1CDK5CDK5R1CAMKK2GSK3B | |
| SCHEMBL29822183 | 0.82 | NUDT1 (0.50) | ALDH1A1ATMPIM1CDK5GSK3B | |
| SCHEMBL28305303 | 0.79 | ALDH1A1 (0.67) | ALDH1A1ATMPIM1MAPK1GPR84 | |
| SCHEMBL3673827 | 0.79 | ALDH1A1 (0.67) | ALDH1A1ATMPIM1MAPK1GPR84 | |
| SCHEMBL18982934 | 0.76 | PIM1 (0.53) | ALDH1A1ATMHTR2CHTR2BHTR5A | |
| SCHEMBL31032166 | 0.75 | PARP1 (0.55) | ALDH1A1MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL28677807 | 0.75 | PARP1 (0.55) | ALDH1A1MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL30108279 | 0.75 | PARP1 (0.55) | ALDH1A1MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL7382969 | 0.75 | ALDH1A1 (0.56) | ALDH1A1ATMPIM1GSK3BDYRK1A | |
| SCHEMBL28035470 | 0.75 | CSNK1A1 (0.49) | ALDH1A1HSD17B10MEN1KMT2ACSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |