Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120415 | 0.91 | — | — | |
| SCHEMBL7114083 | 0.84 | KDM4E (0.36) | PARP1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7116752 | 0.72 | SIRT1 (0.40) | PARP1 | |
| SCHEMBL7122447 | 0.71 | KEAP1 (0.34) | PARP1 | |
| SCHEMBL7114324 | 0.70 | MPO (0.37) | PARP1 | |
| SCHEMBL7123408 | 0.70 | AAK1 (0.33) | — | |
| SCHEMBL7121250 | 0.68 | TSHR (0.41) | PARP1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7116235 | 0.67 | MPO (0.37) | PARP1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7114952 | 0.63 | PARP15 (0.40) | — | |
| SCHEMBL7119320 | 0.62 | PGR (0.40) | PARP1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244629-A2 | QUINOLONE COMPOUNDS FOR USE IN TREATING VIRAL INFECTIONS | GLAXO GROUP LIMITED (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001046150-A2 | QUINOLONE COMPOUNDS FOR USE IN TREATING VIRAL INFECTIONS | GLAXO GROUP LIMITED (GB) | 2001-06-28 | — | — | WO | disclosed |