Sugi Predict

Sugi Predict / Compounds / SCHEMBL754994

SCHEMBL754994

SCHEMBL754994

CN1C(=O)C(=O)c2c(Cl)cccc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES1 P23141 2/20 0.50
▸ TTR P02766 1/20 0.50
▸ TGM2 P21980 1/20 0.46
▸ NSD2 O96028 1/20 0.41
▸ IDO1 P14902 1/20 0.41
▸ TDO2 P48775 1/20 0.41
▸ IDO2 Q6ZQW0 1/20 0.41
▸ ALDH1A1 P00352 4/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ HPGD P15428 1/20 0.39
▸ GABRP O00591 1/20 0.38
▸ GABRD O14764 1/20 0.38
▸ GABRA1 P14867 1/20 0.38
▸ GABRB1 P18505 1/20 0.38
▸ GABRG2 P18507 1/20 0.38
▸ GABRB3 P28472 1/20 0.38
▸ GABRA5 P31644 1/20 0.38
▸ GABRA3 P34903 1/20 0.38
▸ GABRA2 P47869 1/20 0.38
▸ GABRB2 P47870 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756746 0.78 TTR (0.52) CES1TTRALDH1A1CASP3KMT2A
SCHEMBL15323462 0.78 CES1 (0.52) CES1TGM2NSD2IDO1TDO2
SCHEMBL2290914 0.77 TTR (0.50) CES1TTRALDH1A1CASP3KMT2A
SCHEMBL28074688 0.77 TTR (0.50) CES1TTRALDH1A1HPGDCASP3
SCHEMBL1137933 0.77 TTR (0.55) CES1TTRALDH1A1KDM4EHPGD
SCHEMBL6324474 0.77 CES1 (0.41) CES1TTRALDH1A1KDM4EHPGD
SCHEMBL21848273 0.77 TTR (0.50) CES1TTRALDH1A1CASP3KMT2A
SCHEMBL15206754 0.77 TTR (0.50) CES1TTRALDH1A1HPGDCASP3
SCHEMBL28138059 0.77 L3MBTL1 (0.48) TGM2NSD2IDO1TDO2IDO2
SCHEMBL28074698 0.76 TTR (0.48) CES1TTRALDH1A1GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3640247-B1 SYK INHIBITOR AND USE METHOD THEREFOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2022-01-12 — — EP disclosed
US-11091460-B2 Syk inhibitor and use method therefor CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2021-08-17 — — US disclosed
US-11091460-B2 Syk inhibitor and use method therefor CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2021-08-17 — — US disclosed
CN-110678461-B Syk inhibitors and methods of use thereof 正大天晴药业集团股份有限公司 2021-08-10 — — CN disclosed
US-20200199101-A1 SYK INHIBITOR AND USE METHOD THEREFOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2020-06-25 — — US disclosed
US-20200199101-A1 SYK INHIBITOR AND USE METHOD THEREFOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2020-06-25 — — US disclosed
EP-3640247-A1 SYK INHIBITOR AND USE METHOD THEREFOR Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2020-04-22 — — EP disclosed
CN-110678461-A Syk inhibitors and methods of use thereof 正大天晴药业集团股份有限公司 2020-01-10 — — CN disclosed
CN-106749295-B A kind of synthetic method of loop coil Oxoindole gamma-butyrolacton class compound 中国药科大学 2019-04-12 — — CN disclosed
CN-106008309-B A kind of method that visible light catalytic prepares Isatine derivatives 河南大学 2018-05-04 — — CN disclosed
CN-106632315-A Dissymmetrical disubstituted isatin Schiff base type compound with antitumor activity and compounding method thereof 陕西科技大学 2017-05-10 — — CN disclosed
CN-105732476-A Carbazole-isatin type compound and preparation method and application thereof 吉首大学 2016-07-06 — — CN disclosed
CN-105541808-A Metronidazole-isatin type compound as well as preparation method and application thereof UNIV JISHOU 2016-05-04 — — CN disclosed
CN-104829608-A Coumarin-thiazole-indolone compounds, and preparation method and application thereof UNIV JISHOU 2015-08-12 — — CN disclosed
US-20140275175-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2014-09-18 — — US disclosed
US-8778972-B2 5-pyridin-3-yl-1, 3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1 NOVARTIS AG (CH) 2014-07-15 — — US disclosed
WO-2012078519-A2 3-ACYLIDENE-2-OXOINDOLE DERIVATIVES FOR INHIBITION OF TRANSGLUTAMINASE 2 NUMERATE, INC. (US) 2012-06-14 — — WO disclosed
US-20120071512-A1 5-PYRIDIN-3-YL-1, 3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 NOVARTIS AG (CH) 2012-03-22 — — US disclosed
EP-2430011-A1 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 Novartis AG (CH) 2012-03-21 — — EP disclosed
WO-2010130794-A1 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 NOVARTIS AG (CH) 2010-11-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11091460-B2 Syk inhibitor and use method therefor SYK, BTK, LCK CES1 1614/4885TTR 4506/4885TGM2 3466/4885
US-20140275175-A1 ORGANIC COMPOUNDS CYP11B2, CYP11B1, SLCO1B1 CES1 316/4885TTR 1705/4885TGM2 2838/4885
US-20120071512-A1 5-PYRIDIN-3-YL-1, 3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 CYP11B1, HSD11B1, CYP11B2 CES1 163/4885TTR 2114/4885TGM2 4481/4885
US-20200199101-A1 SYK INHIBITOR AND USE METHOD THEREFOR SYK, BTK, LCK CES1 1614/4885TTR 4506/4885TGM2 3466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.