Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221210 | 0.94 | GRIK1 (0.60) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10394714 | 0.94 | GRIK1 (0.60) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| Acrylic Acid SCHEMBL5875513 | 0.89 | GRIK1 (0.54) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27287001 | 0.87 | GRIK1 (0.54) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| Maleic Acid SCHEMBL8995943 | 0.85 | GRIK1 (0.50) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3810332 | 0.85 | GRIK1 (0.52) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| Maleic Acid SCHEMBL8995935 | 0.84 | GRIK1 (0.49) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11327799 | 0.82 | KDM4E (0.52) | GRIK1HCAR2L3MBTL1TDP1LMNA | |
| SCHEMBL7070112 | 0.81 | GRIK1 (0.49) | GRIK1HDAC3HDAC4HDAC1HDAC7 | |
| Maleic Acid SCHEMBL4001893 | 0.81 | ALDH1A1 (0.41) | GRIK1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940266-B1 | A heat mode sensitive imaging element for making positive working printing plates. | AGFA GEVAERT (BE) | 2002-06-26 | — | — | EP | disclosed |
| US-6342336-B2 | CHARACTERIZED IN THAT SAID TOP LAYER CONTAINS A COMPOUND SELECTED FROM THE GROUP CONSISTING OF A POLYMER IN AN AMOUNT FROM 30 MG TO 500 MG/M2, A TRIARYL METHANE DYE AND A PHTHALOCYANINE DYE | AGFA-GEVAERT (BE) | 2002-01-29 | — | — | US | disclosed |
| US-20010001700-A1 | Characterized in that said top layer contains a compound selected from the group consisting of a polymer in an amount from 30 mg to 500 mg/m2, a triaryl methane dye and a phthalocyanine dye | ERIC VERSCHUEREN | 2001-05-24 | — | — | US | disclosed |
| EP-0940266-A1 | A heat mode sensitive imaging element for making positive working printing plates. | AGFA-GEVAERT N.V. (BE) | 1999-09-08 | — | — | EP | disclosed |
| US-4668507-A | (THIO)PHOSPHORYL COMPOUND, SODIUM BENZOATE, DISOCIUM PHOSPHATE, NONIONIC EMULSIFIER, LIQUIFIED HYDROCARBON | S. C. JOHNSON & SON, INC. (US) | 1987-05-26 | — | — | US | disclosed |