Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 6/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL829552 | 0.83 | LMNA (0.40) | ALDH1A1LMNAKDM4EGRIK1POLB | |
| Maleic Acid SCHEMBL7550248 | 0.81 | GRIK1 (0.55) | ALDH1A1LMNAKDM4EHDAC3TNKS | |
| SCHEMBL7584448 | 0.79 | KDM4E (0.45) | ALDH1A1LMNAKDM4EHDAC3GRIK1 | |
| SCHEMBL28759139 | 0.78 | LMNA (0.56) | ALDH1A1LMNAKDM4EHDAC3HDAC4 | |
| Maleic Acid SCHEMBL7175246 | 0.78 | HCAR2 (0.41) | ALDH1A1KDM4EHDAC3TNKSHDAC4 | |
| SCHEMBL10395016 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4EGRIK1POLB | |
| SCHEMBL10395017 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4EGRIK1POLB | |
| SCHEMBL28613781 | 0.76 | LMNA (0.50) | ALDH1A1LMNAHDAC3TNKSHDAC4 | |
| SCHEMBL27890646 | 0.76 | LMNA (0.50) | ALDH1A1LMNAHDAC3TNKSHDAC4 | |
| Maleic Acid SCHEMBL14249678 | 0.75 | HDAC3 (0.44) | ALDH1A1LMNAKDM4EHDAC3TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1394208-B1 | Wheatherable resin compositions having low gloss appearances | INEOS ABS JERSEY LTD (GB) | 2009-06-10 | — | — | EP | claimed |
| EP-0513535-B1 | Glass fibre-reinforced styrene copolymers | BASF AG (DE) | 1995-08-09 | — | — | EP | claimed |
| EP-0513535-A1 | Glass fibre-reinforced styrene copolymers | BASF Aktiengesellschaft (DE) | 1992-11-19 | — | — | EP | claimed |
| EP-0513535-A1 | Glass fibre-reinforced styrene copolymers | BASF Aktiengesellschaft (DE) | 1992-11-19 | — | — | EP | disclosed |
| EP-0513535-A1 | Glass fibre-reinforced styrene copolymers | BASF Aktiengesellschaft (DE) | 1992-11-19 | — | — | EP | disclosed |