Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794415 | 0.86 | DRD3 (0.53) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| SCHEMBL9601079 | 0.84 | HSD11B1 (0.57) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| SCHEMBL9602079 | 0.84 | SLC6A9 (0.55) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL9602476 | 0.83 | DRD3 (0.51) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| SCHEMBL9601398 | 0.83 | DRD2 (0.50) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| Alcohol SCHEMBL9600777 | 0.82 | KMT2A (0.54) | SIGMAR1DRD3DRD2CYP1A2CYP2C9 | |
| Oxalic Acid SCHEMBL9602668 | 0.82 | DRD3 (0.50) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL9603075 | 0.82 | SLC6A2 (0.64) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| SCHEMBL9601559 | 0.82 | SLC6A9 (0.54) | SIGMAR1DRD3DRD2KDM4ECYP1A2 | |
| SCHEMBL7767918 | 0.81 | LMNA (0.53) | SIGMAR1DRD3DRD2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308476-B1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION | Kabi Pharmacia AB (SE) | 1993-02-03 | — | — | EP | disclosed |