Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.32 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547793 | 0.96 | AAK1 (0.35) | AAK1USP2TP53TSHRLEF1 | |
| SCHEMBL7549047 | 0.91 | MAPK14 (0.33) | AAK1NPC1RAB9AALDH1A1LEF1 | |
| SCHEMBL7548911 | 0.88 | AAK1 (0.33) | AAK1 | |
| SCHEMBL7551128 | 0.88 | AAK1 (0.33) | AAK1 | |
| SCHEMBL7550867 | 0.87 | AAK1 (0.32) | AAK1 | |
| SCHEMBL7548644 | 0.87 | MAPK14 (0.32) | AAK1ALDH1A1LEF1NR1I3KDM4E | |
| SCHEMBL7550465 | 0.81 | MAPK14 (0.31) | NR1I3 | |
| SCHEMBL7547271 | 0.81 | RORC (0.31) | NR1I3 | |
| SCHEMBL7547397 | 0.80 | CNR1 (0.32) | ALDH1A1NR1I3KDM4E | |
| SCHEMBL7549039 | 0.78 | ALOX15 (0.32) | ALDH1A1TSHRNR1I3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |