Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515770 | 0.76 | LMNA (0.49) | RAB9AMAPTLMNAEPHX1EPHX2 | |
| SCHEMBL7523868 | 0.73 | LMNA (0.38) | RAB9AMAPTLMNAEPHX1EPHX2 | |
| SCHEMBL7523106 | 0.72 | MEN1 (0.38) | MAPTMEN1KMT2A | |
| SCHEMBL7555795 | 0.69 | POLB (0.40) | RAB9AMAPTLMNAKDRNPC1 | |
| SCHEMBL7515289 | 0.68 | MAPT (0.45) | RAB9AMAPTLMNAEPHX1EPHX2 | |
| SCHEMBL7518027 | 0.68 | RAB9A (0.45) | RAB9AMAPTLMNAEPHX1EPHX2 | |
| SCHEMBL27985529 | 0.65 | EPHX1 (0.61) | RAB9AMAPTLMNAEPHX1EPHX2 | |
| SCHEMBL27524607 | 0.64 | RAB9A (0.44) | RAB9AMAPTLMNAEPHX1EPHX2 | |
| SCHEMBL4090026 | 0.64 | HPGD (0.44) | MAPTLMNATSHRMEN1KMT2A | |
| SCHEMBL23709481 | 0.63 | KMT2A (0.59) | MAPTLMNAKDM4ETSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |