Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799599 | 0.76 | ESR1 (0.37) | SLC18A3CYP2D6CYP2C9GBA1 | |
| SCHEMBL5585965 | 0.70 | KDM4E (0.37) | — | |
| SCHEMBL3069555 | 0.68 | DRD2 (0.38) | — | |
| SCHEMBL22467911 | 0.64 | ADRB2 (0.33) | CYP1A2CYP2C9 | |
| SCHEMBL11224081 | 0.64 | LMNA (0.33) | — | |
| SCHEMBL1828313 | 0.64 | LMNA (0.33) | — | |
| SCHEMBL5392162 | 0.63 | ORAI1 (0.38) | SLC18A3CYP2D6GBA1 | |
| SCHEMBL22468064 | 0.63 | SLC6A2 (0.32) | CYP1A2CYP2C9 | |
| Biphenyl SCHEMBL28309835 | 0.62 | CYP2D6 (0.49) | SLC18A3CYP2D6CYP2C9GBA1 | |
| SCHEMBL76560 | 0.62 | LMNA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891360-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-0891360-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036900-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |