Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of 8-Hydroxy Quinaldine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.59 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8-Hydroxy Quinaldine SCHEMBL297247 | 0.91 | METAP2 (1.00) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL29483489 | 0.91 | METAP2 (1.00) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL27554557 | 0.89 | METAP2 (0.89) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL7179747 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL4304584 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL9154369 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL5089361 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL22734876 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL4762935 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL4401768 | 0.89 | METAP2 (0.96) | METAP2KDM4EALOX12GLO1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6488750-B1 | Inkless fingerprint compound and method | ARMOR HOLDINGS FORENSICS INC. | 2002-12-03 | — | — | US | disclosed |
| WO-2002092705-A1 | INKLESS FINGERPRINT COMPOUND AND METHOD | ARMOR HOLDINGS FORENSICS, INC. (US) | 2002-11-21 | — | — | WO | disclosed |
| US-20020166477-A1 | INKLESS FINGERPRINT COMPOUND AND METHOD | SAFARILAND, LLC | 2002-11-14 | — | — | US | disclosed |