Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 12/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 12/20 | 0.57 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621114 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10ABL1 | |
| SCHEMBL7499867 | 0.78 | ACVR1 (0.56) | ACVR1TGFBR1ACVR1BKDM4EALDH1A1 | |
| SCHEMBL5207666 | 0.76 | TGFBR1 (0.49) | ACVR1TGFBR1ACVR1BKDM4EALDH1A1 | |
| SCHEMBL7562633 | 0.74 | PTGS2 (0.51) | KDM4EALDH1A1MAPTADORA3 | |
| SCHEMBL7563700 | 0.74 | TUBB4A (0.51) | ALDH1A1MAPTFYNMAPK1ADORA3 | |
| SCHEMBL19079607 | 0.74 | TGFBR1 (0.80) | ACVR1TGFBR1ACVR1BBMPR1AACVRL1 | |
| SCHEMBL9829916 | 0.74 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDTSHRCYP3A4 | |
| SCHEMBL10979023 | 0.74 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL5209830 | 0.73 | TGFBR1 (0.52) | ACVR1TGFBR1ACVR1BKDM4EALDH1A1 | |
| SCHEMBL8621175 | 0.73 | MAPT (0.43) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222169-A1 | NOVEL TRISUBSTITUTED PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001025204-A1 | NOVEL TRISUBSTITUTED PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-12 | — | — | WO | disclosed |