Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 2/20 | 0.51 |
| ▸ | TUBB | P07437 | 2/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618775 | 0.80 | MAPT (0.54) | MAPTALDH1A1ADK | |
| SCHEMBL8616869 | 0.80 | KDM4E (0.55) | PDGFRBPDGFRAADORA3MAPTALDH1A1 | |
| SCHEMBL5710084 | 0.80 | KDM4E (0.55) | PDGFRBPDGFRAADORA3MAPTALDH1A1 | |
| SCHEMBL7562633 | 0.79 | PTGS2 (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8622692 | 0.78 | PDGFRB (0.48) | PDGFRBPDGFRAADORA3MAPTALDH1A1 | |
| SCHEMBL25391019 | 0.76 | FYN (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9695159 | 0.76 | LTB4R (0.50) | PDGFRBPDGFRAADORA3MAPTMEN1 | |
| SCHEMBL7504138 | 0.76 | KDM4E (0.60) | MAPTMEN1KMT2AALDH1A1GFER | |
| SCHEMBL7556935 | 0.74 | ACVR1 (0.57) | ADORA3MAPTALDH1A1MAPK1FYN | |
| SCHEMBL18867181 | 0.74 | ALDH1A1 (0.56) | ADORA3MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222169-A1 | NOVEL TRISUBSTITUTED PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001025204-A1 | NOVEL TRISUBSTITUTED PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-12 | — | — | WO | disclosed |