Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151874 | 0.89 | LMNA (0.46) | ALOX5TRPM8LMNACYP2C19ALDH1A1 | |
| SCHEMBL3568466 | 0.89 | TRPM8 (0.41) | ALOX5TRPM8CYP2D6LMNACYP3A4 | |
| SCHEMBL10595995 | 0.86 | ALDH1A1 (0.46) | ALOX5TRPM8CYP2D6SRCLMNA | |
| SCHEMBL27518180 | 0.81 | GAA (0.45) | TRPM8CYP2D6SRCLMNAMAPK1 | |
| SCHEMBL1896509 | 0.81 | GAA (0.45) | TRPM8CYP2D6SRCLMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL10825477 | 0.80 | GAA (0.44) | TRPM8CYP2D6SRCLMNAMAPK1 | |
| SCHEMBL5851718 | 0.78 | ALOX5 (0.42) | ALOX5TRPM8CYP2D6SRCLMNA | |
| SCHEMBL5801209 | 0.78 | TRPM8 (0.47) | ALOX5TRPM8MAPTHSD17B10ALDH1A1 | |
| SCHEMBL28275848 | 0.78 | SRC (0.50) | ALOX5TRPM8CYP2D6SRCLMNA | |
| SCHEMBL27599780 | 0.77 | LMNA (0.46) | TRPM8CYP2D6SRCLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235793-A2 | VLA-4 INTEGRIN ANTAGONISTS | Novartis AG (CH) | 2002-09-04 | — | — | EP | disclosed |
| US-6432923-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | NOVARTIS AG (CH) | 2002-08-13 | — | — | US | disclosed |
| US-6407065-B1 | PREVENT CELL ADHESION; ANTIINFLAMMTORY AGENTS, RESPIRATORY SYSTEM DISORDERS | NOVARTIS AG (CH) | 2002-06-18 | — | — | US | disclosed |
| WO-2001042192-A2 | VLA-4 INTEGRIN ANTAGONISTS | NOVARTIS AG (CH) | 2001-06-14 | — | — | WO | disclosed |
| EP-1049665-A1 | VLA-4 ANTAGONISTS | Novartis AG (Novartis SA) (Novartis Inc.) (CH) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999037605-A1 | VLA-4 ANTAGONISTS | NOVARTIS AG (CH) | 1999-07-29 | — | — | WO | disclosed |