Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568466 | 0.91 | TRPM8 (0.41) | TRPM8MDM2CES2CES1KDM4E | |
| SCHEMBL5802781 | 0.88 | TRPM8 (0.45) | TRPM8MDM2CES2CES1NR1I2 | |
| SCHEMBL5819200 | 0.83 | ALDH1A1 (0.56) | TRPM8MDM2GAANPC1ALDH1A1 | |
| SCHEMBL5801133 | 0.82 | MDM2 (0.39) | MDM2CES2CES1NR1I2KDM4E | |
| SCHEMBL5819192 | 0.80 | NPC1 (0.49) | TRPM8MDM2GAANPC1ALDH1A1 | |
| SCHEMBL5803975 | 0.80 | MDM2 (0.34) | TRPM8MDM2CES2CES1NPC1 | |
| SCHEMBL7560686 | 0.78 | ALOX5 (0.44) | TRPM8NR1I2ALOX5ALDH1A1MAPT | |
| SCHEMBL3563022 | 0.78 | MDM2 (0.41) | MDM2CES2CES1NR1I2KDM4E | |
| SCHEMBL3563412 | 0.76 | PPARA (0.38) | MDM2CES2CES1GAANPC1 | |
| SCHEMBL3569300 | 0.76 | CNR2 (0.41) | MDM2CES2CES1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006063113-A2 | UREAS AS FACTOR XA INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | claimed |