Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561006 | 0.94 | SMN1; SMN2 (0.44) | SMN1; SMN2F10F2NPC1RAB9A | |
| SCHEMBL7561981 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2MMP12MMP13 | |
| SCHEMBL7561384 | 0.90 | ALDH1A1 (0.43) | SMN1; SMN2HPGDALDH1A1HTTMMP12 | |
| SCHEMBL7567148 | 0.89 | NPC1 (0.38) | SMN1; SMN2F10F2NPC1RAB9A | |
| SCHEMBL7563408 | 0.86 | NPSR1 (0.47) | SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL7561001 | 0.86 | MMP13 (0.39) | SMN1; SMN2HPGDALDH1A1HTTPPARG | |
| SCHEMBL7563170 | 0.85 | NPSR1 (0.45) | SMN1; SMN2F10F2NPSR1 | |
| SCHEMBL7570883 | 0.80 | LMNA (0.46) | SMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL7567526 | 0.77 | HRH4 (0.44) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL9188639 | 0.75 | PPID (0.52) | SMN1; SMN2F10F2PPIDLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882703-B1 | CYCLIC AMIC ACID DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-6011174-A | INHIBIT PROTEIN-FARNESYL TRANSFERASE (PFT) IN VIVO THEREBY TO SUPPRESS FUNCTION OF ONCOGENE PROTEIN RAS AND THUS PRESENT ANTITUMOR ACTIVITIES, | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0882703-A1 | CYCLIC AMIC ACID DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |