Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684390 | 0.88 | CA2 (0.45) | CA2MAOACISD1MAOBPTGS2 | |
| SCHEMBL7971444 | 0.87 | MAOA (0.67) | CA2MAOACISD1MAOBPTGS2 | |
| SCHEMBL8537473 | 0.78 | CA2 (0.54) | CA2MAOACISD1MAOBALDH1A1 | |
| SCHEMBL30020280 | 0.76 | PTGS2 (0.48) | CA2PTGS2PTGS1ALDH1A1TSHR | |
| Tazofelone SCHEMBL7562446 | 0.74 | ALDH1A1 (0.40) | MAOACISD1MAOBPTGS2PTGS1 | |
| Tazofelone SCHEMBL380266 | 0.74 | ALDH1A1 (0.40) | MAOACISD1MAOBPTGS2PTGS1 | |
| Tazofelone SCHEMBL7561505 | 0.74 | ALDH1A1 (0.40) | MAOACISD1MAOBPTGS2PTGS1 | |
| SCHEMBL8172791 | 0.74 | CA2 (0.71) | CA2MAOACISD1MAOBALDH1A1 | |
| SCHEMBL13045143 | 0.73 | GAA (0.46) | CA2ALDH1A1TSHRNPSR1MEN1 | |
| SCHEMBL21263121 | 0.72 | ALDH1A1 (0.41) | CA2MAOACISD1MAOBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799215-B1 | PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES | LILLY CO ELI (US) | 2002-08-14 | — | — | EP | disclosed |
| US-6201127-B1 | REACTING 2-THIOXO-4-THIAZOLIDINONE, 2,4-THIAZOLIDINEDIONE OR 4-THIAZOLIDNONE WITH AN ALDEHYDE IN THE PRESENCE OF AN AMINE | ELI LILLY AND COMPANY | 2001-03-13 | — | — | US | disclosed |
| EP-0761656-B1 | Alternate crystal form of tazofelone ((+,-)-5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methyl)-4-thiazolidinone) | LILLY CO ELI (US) | 2001-01-03 | — | — | EP | disclosed |
| EP-0761657-B1 | Process for preparing benzyl-substituted rhodanine derivatives | LILLY CO ELI (US) | 2000-05-24 | — | — | EP | disclosed |
| US-6063799-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL DISORDERS AND ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-05-16 | — | — | US | disclosed |
| US-6005142-A | Process for preparing benzyl-substituted rhodanine derivatives | ELI LILLY AND COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0434394-B1 | Compounds for treating inflammatory bowel disease | LILLY CO ELI (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1997009320-A1 | ALTERNATE CRYSTAL FORM OF TAZOFELONE | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |
| WO-1997009305-A1 | PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5387690-A | Method of treating inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1995-02-07 | — | — | US | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5216002-A | Using benzyl substituted rhodanine derivatives as pure enantiomeric form | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0434394-A2 | Compounds for treating inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0391644-A2 | Aryl-substituted rhodanine derivatives | ELI LILLY AND COMPANY (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0211670-B1 | DI-T-BUTYLPHENOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1990-05-09 | — | — | EP | disclosed |
| EP-0211670-A2 | Di-t-butylphenol compounds | ELI LILLY AND COMPANY (US) | 1987-02-25 | — | — | EP | disclosed |