Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.38 |
| ▸ | ITGAL | P20701 | 3/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.33 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564924 | 0.80 | KDM4E (0.36) | ITGB2ICAM1ITGAL | |
| SCHEMBL7536650 | 0.76 | MMP2 (0.38) | ITGB2ICAM1ITGALCAPN1 | |
| SCHEMBL7201321 | 0.76 | PSMB5 (0.40) | PSMB5ITGB2ICAM1ITGALPYGL | |
| SCHEMBL7536449 | 0.72 | MMP2 (0.36) | — | |
| SCHEMBL7543444 | 0.70 | CASP3 (0.49) | — | |
| SCHEMBL7432924 | 0.68 | FBP1 (0.50) | — | |
| SCHEMBL7535627 | 0.66 | CASP3 (0.40) | — | |
| SCHEMBL17969599 | 0.65 | FEN1 (0.42) | ITGB2ICAM1ITGAL | |
| SCHEMBL20815821 | 0.62 | PSMB5 (0.55) | PSMB5ITGB2ICAM1ITGALITGB1 | |
| SCHEMBL20815818 | 0.62 | PSMB5 (0.55) | PSMB5ITGB2ICAM1ITGALITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159291-A1 | C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYLCARBONYLDIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals, Inc. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2001000658-A1 | C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYLCARBONYLDIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2001-01-04 | — | — | WO | disclosed |