SCHEMBL7562987

SCHEMBL7562987

CCOC(=O)c1cc(C=O)c([N+](=O)[O-])[nH]1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.42
ALDH1A1 P00352 5/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
HPGD P15428 4/20 0.42
KDM4E B2RXH2 3/20 0.42
RAB9A P51151 3/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPT P10636 2/20 0.41
NPC1 O15118 3/20 0.41
KMT2A Q03164 3/20 0.41
LMNA P02545 3/20 0.41
MEN1 O00255 2/20 0.41
GLA P06280 1/20 0.41
GAA P10253 1/20 0.41
ATM Q13315 1/20 0.41
POLB P06746 2/20 0.40
CACNA1F O60840 2/20 0.40
CACNA1D Q01668 2/20 0.40
CACNA1S Q13698 2/20 0.40
CACNA1C Q13936 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16549876 0.80 HPGD (0.43) ARALDH1A1SMN1; SMN2HPGDKDM4E
SCHEMBL3281546 0.79 SMN1; SMN2 (0.50) ALDH1A1SMN1; SMN2HPGDKDM4ERAB9A
SCHEMBL7559710 0.78 ALDH1A1 (0.47) ARALDH1A1SMN1; SMN2HPGDKDM4E
SCHEMBL27074412 0.74 ALDH1A1 (0.46) ARALDH1A1SMN1; SMN2HPGDKDM4E
SCHEMBL9650786 0.74 ALDH1A1 (0.48) ARALDH1A1SMN1; SMN2HPGDKDM4E
SCHEMBL9650225 0.72 ALDH1A1 (0.47) ARALDH1A1SMN1; SMN2HPGDKDM4E
Potassium Ion SCHEMBL9650212 0.72 ALDH1A1 (0.47) ARALDH1A1SMN1; SMN2HPGDKDM4E
SCHEMBL1775446 0.71 ALOX15 (0.48) ALDH1A1SMN1; SMN2HPGDKDM4ERAB9A
SCHEMBL7518403 0.70 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2HPGDRAB9AMAPT
SCHEMBL12501407 0.70 NPC1 (0.48) ARALDH1A1SMN1; SMN2HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1173414-A1 N-PROTECTED AMINES AND THEIR USE AS PRODRUGS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2002-01-23 EP disclosed
WO-2000064864-A9 N-PROTECTED AMINES AND THEIR USE AS PRODRUGS CANCER RES CAMPAIGN TECH (GB) 2001-12-27 WO disclosed
WO-2000064864-A1 N-PROTECTED AMINES AND THEIR USE AS PRODRUGS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2000-11-02 WO disclosed