Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6219348 | 0.85 | MTTP (0.48) | HTR7KCNA3ADRA1DADRA1AADRA1B | |
| Bicarbonate SCHEMBL7565338 | 0.84 | HTR7 (0.43) | HTR7KCNA3ADRA1DADRA1AADRA1B | |
| Bicarbonate SCHEMBL7570482 | 0.82 | SLC6A12 (0.47) | HTR7KCNA3ADRA1DADRA1AADRA1B | |
| Bicarbonate SCHEMBL6219363 | 0.82 | MTTP (0.47) | HTR7ADRA1AHTR1APOLBMEN1 | |
| Bicarbonate SCHEMBL6216666 | 0.82 | MTTP (0.58) | HTR7ADRA1DADRA1AADRA1BDRD4 | |
| Bicarbonate SCHEMBL7570498 | 0.81 | MTTP (0.48) | HTR7ADRA1DADRA1AADRA1BCARM1 | |
| Bicarbonate SCHEMBL6217318 | 0.81 | POLB (0.47) | HTR7KCNA3ADRA1APOLBDRD4 | |
| Bicarbonate SCHEMBL7564901 | 0.80 | POLB (0.48) | HTR7KCNA3ADRA1AHTR1APOLB | |
| SCHEMBL7234349 | 0.78 | HTR7 (0.50) | HTR7KCNA3ADRA1AHTR1APOLB | |
| Bicarbonate SCHEMBL7568719 | 0.77 | CCR3 (0.46) | HTR7ADRA1AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |