Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565747 | 0.92 | POLB (0.48) | POLBHTR7MCHR1MAOBDRD4 | |
| Bicarbonate SCHEMBL6217318 | 0.91 | POLB (0.47) | POLBHTR7DRD4KCNA3CCR3 | |
| Bicarbonate SCHEMBL7565748 | 0.91 | POLB (0.50) | POLBHTR7MCHR1MAOBDRD4 | |
| Bicarbonate SCHEMBL7570482 | 0.89 | SLC6A12 (0.47) | HTR7DRD4KCNA3CCR3HTR1A | |
| Bicarbonate SCHEMBL7565338 | 0.89 | HTR7 (0.43) | POLBHTR7MAOBDRD4KCNA3 | |
| Bicarbonate SCHEMBL7570498 | 0.88 | MTTP (0.48) | HTR7DRD4CCR3CHRM1ADRA2A | |
| SCHEMBL7571721 | 0.87 | POLB (0.47) | POLBHTR7MCHR1MAOBDRD4 | |
| Bicarbonate SCHEMBL7568719 | 0.84 | CCR3 (0.46) | HTR7MCHR1DRD4CCR3CHRM1 | |
| Bicarbonate SCHEMBL6219348 | 0.83 | MTTP (0.48) | POLBHTR7DRD4KCNA3CCR3 | |
| SCHEMBL6217670 | 0.83 | POLB (0.47) | POLBHTR7DRD4KCNA3CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |