Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7564901 | 0.92 | POLB (0.48) | POLBDRD4DRD3DRD2HTR1A | |
| SCHEMBL6217670 | 0.91 | POLB (0.47) | POLBDRD4DRD3ADRA2ADRD1 | |
| Bicarbonate SCHEMBL7565748 | 0.89 | POLB (0.50) | POLBDRD4MCHR1MAOBTSHR | |
| SCHEMBL7569221 | 0.89 | KCNA3 (0.42) | POLBDRD4DRD3HTR1AADRA2A | |
| SCHEMBL7570284 | 0.89 | SLC6A12 (0.47) | DRD4HTR1AHTR2AADRA1ASLC6A4 | |
| SCHEMBL7571721 | 0.89 | POLB (0.47) | POLBDRD4MCHR1MAOBSLC6A2 | |
| SCHEMBL7237786 | 0.85 | POLB (0.46) | POLBDRD4DRD3ADRA2ADRD1 | |
| SCHEMBL7241401 | 0.84 | POLB (0.45) | POLBDRD4DRD3ADRA2ADRD1 | |
| SCHEMBL7235931 | 0.84 | HTR7 (0.48) | POLBDRD4DRD3DRD2HTR1A | |
| SCHEMBL6220682 | 0.83 | MTTP (0.48) | POLBDRD4DRD3ADRA2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |