Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7564901 | 0.91 | POLB (0.48) | POLBMCHR1MAOBDRD4TSHR | |
| Bicarbonate SCHEMBL6217672 | 0.90 | POLB (0.49) | POLBMCHR1DRD4CCR3CHRM1 | |
| SCHEMBL7565747 | 0.89 | POLB (0.48) | POLBMCHR1MAOBDRD4TSHR | |
| Bicarbonate SCHEMBL7569224 | 0.89 | HTR7 (0.43) | POLBMAOBDRD4CCR3CHRM1 | |
| Bicarbonate SCHEMBL7570288 | 0.89 | SLC6A12 (0.49) | POLBDRD4CCR3HTR7HTR4 | |
| SCHEMBL7571721 | 0.86 | POLB (0.47) | POLBMCHR1MAOBDRD4TSHR | |
| Bicarbonate SCHEMBL7568842 | 0.83 | CCR3 (0.48) | MCHR1DRD4CCR3CHRM1HTR7 | |
| Bicarbonate SCHEMBL6220685 | 0.82 | MTTP (0.49) | POLBDRD4CCR3CHRM1HTR7 | |
| Bicarbonate SCHEMBL6219322 | 0.81 | MTTP (0.49) | POLBDRD4CCR3CHRM1HTR7 | |
| Bicarbonate SCHEMBL6217318 | 0.81 | POLB (0.47) | POLBDRD4CCR3CHRM1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |