Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035361 | 0.84 | OPRD1 (0.50) | OPRD1USP30OPRM1ACHESLC6A2 | |
| SCHEMBL8716953 | 0.79 | GPR88 (0.53) | GPR88OPRD1KMT2AUSP30OPRM1 | |
| SCHEMBL14194158 | 0.78 | OPRM1 (0.48) | GPR88OPRD1KMT2AUSP30OPRM1 | |
| Trifluoroacetic Acid SCHEMBL3039321 | 0.78 | OPRD1 (0.52) | OPRD1OPRM1ACHESLC6A2SLC6A4 | |
| SCHEMBL5870760 | 0.77 | OPRM1 (0.54) | OPRD1KMT2AOPRM1SLC6A2SLC6A4 | |
| SCHEMBL10869689 | 0.76 | KMT2A (0.53) | GPR88KMT2AUSP30SLC6A2SLC6A4 | |
| SCHEMBL7494118 | 0.75 | KMT2A (0.45) | GPR88OPRD1KMT2AUSP30OPRM1 | |
| SCHEMBL9996441 | 0.74 | GHSR (0.48) | GPR88KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3611085 | 0.74 | GHSR (0.48) | GPR88KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6287512 | 0.74 | KMT2A (0.45) | GPR88KMT2AUSP30SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187810-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000071518-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2000-11-30 | — | — | WO | disclosed |