Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18843564 | 0.92 | PPARG (0.39) | MGLLPPARGPPARANR1H4TSHR | |
| SCHEMBL9705583 | 0.92 | PPARG (0.39) | MGLLPPARGPPARANR1H4TSHR | |
| SCHEMBL16601922 | 0.85 | ALDH1A1 (0.44) | TSHRALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL9705901 | 0.84 | NPSR1 (0.40) | MGLLPPARGPPARATSHRALDH1A1 | |
| SCHEMBL7563538 | 0.83 | LMNA (0.43) | PPARGPPARANR1H4TSHRALDH1A1 | |
| SCHEMBL8953609 | 0.82 | CA1 (0.42) | NR1H4TSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL25188378 | 0.82 | PPARG (0.42) | PPARGPPARANR1H4TSHRALDH1A1 | |
| SCHEMBL8953650 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1MAPK1POLBSMN1; SMN2ALOX15 | |
| SCHEMBL12550510 | 0.80 | HSP90AA1 (0.49) | PPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL9705548 | 0.78 | NR1H4 (0.56) | NR1H4ALDH1A1MLYCDSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250332-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | Abbott Laboratories (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001044223-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | ABBOTT LABORATORIES (US) | 2001-06-21 | — | — | WO | disclosed |
| US-5446062-A | Antiallergens, antiinflammatory agent | ABBOTT LABORATORIES (US) | 1995-08-29 | — | — | US | disclosed |
| US-5432194-A | Antiallergens, antinflammatory agents | ABBOTT LABORATORIES (US) | 1995-07-11 | — | — | US | disclosed |
| WO-1994026264-A1 | (4-ALKOXYPYRAN-4-YL) SUBSTITUTED ARYLALKYLARYL-, ARYLALKENYLARYL-, AND ARYLALKYNYLARYLUREA INHIBITORS OF 5-LIPOXYGENASE | ABBOTT LABORATORIES (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5346914-A | Antiallergens, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |