Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431532 | 0.80 | KIF11 (0.38) | — | |
| SCHEMBL7025055 | 0.78 | ADORA2B (0.40) | IDO1MAP4K4MINK1TNIKMAPK1 | |
| SCHEMBL7021958 | 0.78 | IDO1 (0.37) | AAK1IDO1MAPK14SYKMAP4K4 | |
| SCHEMBL2426847 | 0.76 | CYP11B2 (0.43) | IDO1SCN9A | |
| SCHEMBL2013844 | 0.76 | CYP11B2 (0.33) | — | |
| SCHEMBL7022407 | 0.75 | PDE10A (0.39) | AAK1IDO1MAPK14SYKADORA2B | |
| SCHEMBL2433532 | 0.74 | NR1H2 (0.35) | TRPV1MAPT | |
| SCHEMBL1369135 | 0.73 | KIF11 (0.39) | IDO1SCN9A | |
| SCHEMBL8323540 | 0.73 | NOTUM (0.40) | IDO1MAP4K4MAPK1 | |
| SCHEMBL9586460 | 0.73 | APP (0.42) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109803-A4 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-10-29 | — | — | EP | disclosed |
| EP-1109803-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001022965-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2001-04-05 | — | — | WO | disclosed |
| WO-2000006563-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |