Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570202 | 0.86 | P2RX7 (1.00) | P2RX7CA2 | |
| SCHEMBL2881946 | 0.80 | P2RX7 (0.65) | P2RX7 | |
| SCHEMBL7570486 | 0.78 | P2RX7 (0.64) | P2RX7CA2MEN1ALDH1A1KMT2A | |
| SCHEMBL3454922 | 0.78 | P2RX7 (1.00) | P2RX7CA2EPHX2 | |
| SCHEMBL7571588 | 0.77 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL7571523 | 0.77 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17483924 | 0.77 | P2RX7 (0.75) | P2RX7CA2EPHX2 | |
| SCHEMBL14764889 | 0.76 | P2RX7 (0.73) | P2RX7CA2EPHX2MEN1KMT2A | |
| SCHEMBL4879622 | 0.76 | P2RX7 (0.73) | P2RX7CA2EPHX2 | |
| SCHEMBL19321961 | 0.75 | P2RX7 (0.63) | P2RX7CA2EPHX2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |