Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382380 | 1.00 | DRD2 (0.53) | DRD2DRD4DRD3TSHRUSP2 | |
| SCHEMBL1382258 | 0.87 | ATM (0.56) | TSHRKMT2A | |
| SCHEMBL7572169 | 0.86 | PKM (0.57) | TSHRUSP2KMT2A | |
| SCHEMBL1383323 | 0.86 | CHRNA7 (0.49) | DRD2DRD4DRD3TSHRUSP2 | |
| SCHEMBL1381988 | 0.86 | CHRNA7 (0.49) | DRD2DRD4DRD3TSHRUSP2 | |
| SCHEMBL7572390 | 0.85 | KDM4E (0.58) | TSHRUSP2MEN1KMT2ACACNA1G | |
| SCHEMBL7572751 | 0.84 | HRH1 (0.49) | DRD2DRD4DRD3TSHRUSP2 | |
| SCHEMBL7565949 | 0.81 | KDM4E (0.51) | DRD2DRD3USP2MEN1KMT2A | |
| SCHEMBL7588884 | 0.80 | ADRB3 (0.44) | TSHRMEN1KMT2ACACNA1GKCNH2 | |
| SCHEMBL5368959 | 0.80 | DRD2 (0.57) | DRD2DRD4DRD3TSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216244-A1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019821-A1 | BENZISOXAZOLYL-, PYRIDOISOXAZOLYL- AND BENZTHIENYL-PHENOXY DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-03-22 | — | — | WO | disclosed |