Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382258 | 0.91 | ATM (0.56) | KDM4ETSHRSMN1; SMN2KMT2AABCB1 | |
| SCHEMBL7572390 | 0.89 | KDM4E (0.58) | KDM4EALDH1A1USP2TSHRKMT2A | |
| SCHEMBL7565949 | 0.87 | KDM4E (0.51) | PKMKDM4EALDH1A1USP2MAPK1 | |
| SCHEMBL1382380 | 0.86 | DRD2 (0.53) | USP2TSHRKMT2A | |
| SCHEMBL7570879 | 0.86 | DRD2 (0.53) | USP2TSHRKMT2A | |
| SCHEMBL1381988 | 0.85 | CHRNA7 (0.49) | PKMUSP2TSHR | |
| SCHEMBL1383323 | 0.85 | CHRNA7 (0.49) | PKMUSP2TSHR | |
| SCHEMBL7588884 | 0.82 | ADRB3 (0.44) | ALDH1A1TSHRSMN1; SMN2KMT2AABCB1 | |
| SCHEMBL7573958 | 0.82 | CACNA1G (0.48) | MAPK1KMT2ALMNA | |
| SCHEMBL7569775 | 0.82 | HTR1A (0.53) | KDM4EALDH1A1USP2TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216244-A1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019821-A1 | BENZISOXAZOLYL-, PYRIDOISOXAZOLYL- AND BENZTHIENYL-PHENOXY DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-03-22 | — | — | WO | disclosed |