Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7569682 | 0.90 | HRH3 (0.40) | OPRM1OPRD1OPRK1OPRL1HRH3 | |
| SCHEMBL30909064 | 0.81 | OPRM1 (0.58) | OPRM1OPRD1OPRK1OPRL1HRH3 | |
| SCHEMBL6775059 | 0.81 | OPRM1 (0.58) | OPRM1OPRD1OPRK1OPRL1HRH3 | |
| SCHEMBL30909174 | 0.77 | OPRM1 (0.56) | OPRM1OPRD1OPRK1OPRL1HRH3 | |
| SCHEMBL6742428 | 0.76 | HTR7 (0.50) | OPRM1OPRD1OPRK1OPRL1HTR6 | |
| SCHEMBL29856216 | 0.72 | GSK3B (0.53) | MAPTAOC3KCNH2KDM4CCYP19A1 | |
| SCHEMBL7568482 | 0.71 | MAPT (0.42) | KDM2BMAPTCYP19A1 | |
| SCHEMBL24110238 | 0.70 | MAPT (0.39) | MAPTAOC3CYP19A1CDK4 | |
| SCHEMBL7002395 | 0.69 | HTR6 (0.39) | OPRM1OPRD1OPRK1OPRL1HRH3 | |
| SCHEMBL7497513 | 0.68 | OPRM1 (0.34) | OPRM1OPRD1OPRK1OPRL1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204662-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2002-05-15 | — | — | EP | claimed |
| WO-2001012629-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP. (US) | 2001-02-22 | — | — | WO | claimed |
| EP-1204662-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001012629-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP. (US) | 2001-02-22 | — | — | WO | disclosed |