SCHEMBL7570901

SCHEMBL7570901

Nc1nc2c(ncn2CCC(=O)NCCc2ccc(S(N)(=O)=O)cc2)c(=O)[nH]1

nearest known ligand 0.55

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA1 P00915 8/20 0.55
CA2 P00918 8/20 0.55
CA9 Q16790 7/20 0.55
CA4 P22748 3/20 0.55
HPRT1 P00492 1/20 0.48
TK1 P04183 1/20 0.48
ALDH1A1 P00352 1/20 0.48
POLB P06746 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
CA12 O43570 1/20 0.48
HSD17B10 Q99714 1/20 0.47
PNP P00491 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7397963 0.87 CA1 (0.59) CA1CA2CA9CA4HPRT1
SCHEMBL7575116 0.81 TK1 (0.59) HPRT1TK1HSD17B10PNP
SCHEMBL7570078 0.81 TK1 (0.65) HPRT1TK1ALDH1A1HSD17B10PNP
SCHEMBL7980835 0.80 HPRT1 (0.50) HPRT1TK1HSD17B10PNP
SCHEMBL7576803 0.80 TK1 (0.60) HPRT1TK1PNP
SCHEMBL7982329 0.80 TK1 (0.57) HPRT1TK1HSD17B10PNP
SCHEMBL7567095 0.78 TK1 (0.60) HPRT1TK1HSD17B10PNP
SCHEMBL7586861 0.78 HINT1 (0.57) HPRT1TK1ALDH1A1PNP
SCHEMBL7572289 0.78 TK1 (0.60) HPRT1TK1ALDH1A1HSD17B10PNP
SCHEMBL7567140 0.77 PNP (0.64) HPRT1TK1ALDH1A1POLBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1237890-A1 SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES Neotherapeutics, Inc. (US) 2002-09-11 EP claimed
US-6297226-B1 TREATING A DISEASE OR A CONDITION IN A MAMMAL TREATABLE BY INHIBITING THE ACTIVITY OF A MONOAMINE OXIDASE NEOTHERAPEUTICS, INC. 2001-10-02 US claimed
WO-2001029039-A1 SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES NEOTHERAPEUTICS, INC. (US) 2001-04-26 WO claimed
EP-1237890-A1 SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES Neotherapeutics, Inc. (US) 2002-09-11 EP disclosed
US-6297226-B1 TREATING A DISEASE OR A CONDITION IN A MAMMAL TREATABLE BY INHIBITING THE ACTIVITY OF A MONOAMINE OXIDASE NEOTHERAPEUTICS, INC. 2001-10-02 US disclosed
WO-2001029039-A1 SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES NEOTHERAPEUTICS, INC. (US) 2001-04-26 WO disclosed