Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.44 |
| ▸ | FNTB | P49356 | 7/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 7/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15201578 | 0.85 | FNTA (0.44) | FNTAFNTBPGGT1BS1PR1S1PR3 | |
| SCHEMBL7221989 | 0.85 | CYP11B2 (0.46) | FNTAFNTBPGGT1BS1PR1S1PR3 | |
| SCHEMBL15201291 | 0.82 | VNN1 (0.47) | FNTAFNTBPGGT1BS1PR1S1PR3 | |
| SCHEMBL7572471 | 0.80 | FNTA (0.54) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7569980 | 0.79 | FNTA (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL5088981 | 0.78 | CYP11B1 (0.50) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL15201791 | 0.76 | VNN1 (0.46) | VNN1 | |
| SCHEMBL7593867 | 0.76 | RBP4 (0.43) | FNTAFNTBPGGT1B | |
| SCHEMBL15201717 | 0.76 | LMNA (0.49) | FNTAFNTBALDH1A1MEN1KMT2A | |
| SCHEMBL7182213 | 0.75 | FNTA (0.57) | FNTAFNTBPGGT1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814814-B1 | IMIDAZOLYLKETONE DERIVATIVES ASD ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-05-08 | — | — | EP | claimed |
| US-9464058-B2 | Imidazolylketone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-10-11 | — | — | US | claimed |
| EP-2814814-B1 | IMIDAZOLYLKETONE DERIVATIVES ASD ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-05-08 | — | — | EP | disclosed |
| US-9464058-B2 | Imidazolylketone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20140128429-A1 | NEW IMIDAZOLYLKETONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-20020019527-A1 | Substituted phenyl farnesyltransferase inhibitors | ABBOTT LABORATORIES | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128429-A1 | NEW IMIDAZOLYLKETONE DERIVATIVES | KCNK4, NEK5, FN3KRP | FNTA 2919/4885FNTB 1814/4885PGGT1B 2921/4885 |
| US-20020019527-A1 | Substituted phenyl farnesyltransferase inhibitors | FNTA, FNTB, SLC10A1 | FNTA 1/4885FNTB 2/4885PGGT1B 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.