Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31259763 | 0.84 | RAB9A (0.55) | LMNAL3MBTL1KMT2ARAB9ATDP1 | |
| SCHEMBL25329826 | 0.84 | RAB9A (0.55) | LMNAL3MBTL1KMT2ARAB9ATDP1 | |
| SCHEMBL29242263 | 0.77 | LMNA (0.73) | LMNAL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL29067692 | 0.77 | LMNA (0.73) | LMNAL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL10458609 | 0.77 | LMNA (0.73) | LMNAL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL10458600 | 0.77 | LMNA (0.73) | LMNAL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL21243071 | 0.75 | LMNA (0.82) | LMNAL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL4478304 | 0.75 | RAB9A (0.59) | LMNARAB9AFAAHPTGS1PTGS2 | |
| SCHEMBL4482367 | 0.75 | RAB9A (0.59) | LMNARAB9AFAAHPTGS1PTGS2 | |
| SCHEMBL14937203 | 0.74 | L3MBTL1 (0.72) | LMNAL3MBTL1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020160988-A1 | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH | 2002-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160988-A1 | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof | CHAT, ACHE, CHRNB2 | LMNA 4005/4885L3MBTL1 1442/4885MAPT 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.