Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588944 | 0.86 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL164503 | 0.83 | RECQL (0.76) | RECQLKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7573136 | 0.83 | KEAP1 (0.76) | RECQLKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7571609 | 0.83 | MAPT (0.54) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL1428546 | 0.82 | RECQL (1.00) | RECQLKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL23555160 | 0.80 | ALDH1A1 (0.71) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL9942077 | 0.80 | RECQL (0.71) | RECQLKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7537943 | 0.80 | RECQL (0.76) | RECQLKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7578880 | 0.80 | KEAP1 (0.76) | RECQLKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL18434691 | 0.79 | KEAP1 (0.78) | RECQLKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |