Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | BRD1 | O95696 | 1/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588944 | 0.86 | ALDH1A1 (0.56) | MAPTSMN1; SMN2TP53GAACCR2 | |
| SCHEMBL7596280 | 0.83 | CCR2 (0.56) | MAPTSMN1; SMN2TP53GAACCR2 | |
| SCHEMBL7572140 | 0.83 | RECQL (0.69) | MAPTGAAMEN1KMT2AKEAP1 | |
| SCHEMBL7571483 | 0.81 | LMNA (0.67) | MAPTSMN1; SMN2MEN1KMT2AKEAP1 | |
| SCHEMBL27790749 | 0.81 | ATM (0.73) | MAPTSMN1; SMN2TP53GAAMEN1 | |
| SCHEMBL7577515 | 0.81 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL23555160 | 0.81 | ALDH1A1 (0.71) | MAPTGAAMEN1KMT2AKEAP1 | |
| SCHEMBL7597807 | 0.79 | CCR2 (0.71) | CCR2PGRLMNA | |
| SCHEMBL7573875 | 0.79 | KEAP1 (0.55) | MAPTSMN1; SMN2GAACCR2MEN1 | |
| SCHEMBL7590023 | 0.78 | CCR2 (0.51) | MAPTSMN1; SMN2TP53GAACCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |