Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28143046 | 0.84 | TSHR (0.31) | ALDH1A1TSHR | |
| Water SCHEMBL28770543 | 0.84 | TSHR (0.31) | ALDH1A1TSHR | |
| Thiocyanic Acid SCHEMBL757270 | 0.82 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| Cyanate SCHEMBL1073067 | 0.82 | CA1 (0.35) | CA1CA2ALDH1A1TSHR | |
| SCHEMBL11780486 | 0.82 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| Cyanate SCHEMBL1073063 | 0.82 | ALDH1A1 (0.33) | CA1CA2ALDH1A1TSHR | |
| SCHEMBL11780479 | 0.82 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| Water SCHEMBL27550759 | 0.81 | — | — | |
| SCHEMBL197824 | 0.80 | TSHR (0.33) | ALDH1A1TSHR | |
| Hydrogen Sulfide SCHEMBL28090943 | 0.80 | TSHR (0.33) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3808737-A1 | PROCESSES FOR PREPARING MEDICAMENTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR USE THEREIN | BIAL - Portela & Ca., S.A. (PT) | 2021-04-21 | — | — | EP | claimed |
| EP-2577003-B1 | METHOD AND APPARATUS FOR OPERATING A STEAM CYCLE PROCESS WITH A LUBRICATED EXPANDER | MAN TRUCK & BUS AG (DE) | 2018-07-18 | — | — | EP | claimed |
| US-20160221981-A1 | Processes for Preparing Medicaments for the Treatment of Cardiovascular Diseases and Intermediates for Use Therein | BIAL-PORTELA & CA., S.A. (PT) | 2016-08-04 | — | — | US | claimed |
| EP-3044215-A1 | PROCESSES FOR PREPARING MEDICAMENTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR USE THEREIN | Bial-Portela & CA, S.A. (PT) | 2016-07-20 | — | — | EP | claimed |
| US-9382816-B2 | Method and apparatus for operating a steam cycle process with a lubricated expander | MAN TRUCK & BUS AG (DE) | 2016-07-05 | — | — | US | claimed |
| EP-1507761-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES AND THEIR USE AS PESTICIDES | MERIAL INC (US) | 2016-02-24 | — | — | EP | claimed |
| WO-2015038022-A1 | PROCESSES FOR PREPARING MEDICAMENTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR USE THEREIN | BIAL - PORTELA & CA., S.A. (PT) | 2015-03-19 | — | — | WO | claimed |
| US-20130263598-A1 | Method and Apparatus for Operating a Steam Cycle Process with a Lubricated Expander | MAN TRUCK & BUS AG (DE) | 2013-10-10 | — | — | US | claimed |
| EP-1911757-B1 | Method of preparation of 3-(1,3-Dihydroimidazole-2-thione-1-yl)-chromanes and thiochromanes as dopamine-beta-hydroxylase inhibitors | PORTELA & CA SA (PT) | 2011-03-02 | — | — | EP | claimed |
| EP-2217585-A2 | PROCESS FOR THE PREPARATION OF 2H-CHROMENE-3-CARBAMATE DERIVATIVES | BIAL - Portela & Ca., S.A. (PT) | 2010-08-18 | — | — | EP | claimed |
| US-7125904-B2 | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation | PORTELA & C.A., S.A. (PT) | 2006-10-24 | — | — | US | claimed |
| US-20060166991-A1 | Pyridine carboxamide derivatives and their use as pesticides | BAYER CROPSCIENCE GMBH (DE) | 2006-07-27 | — | — | US | claimed |
| EP-1507761-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES AND THEIR USE AS PESTICIDES | Bayer CropScience GmbH (DE) | 2005-02-23 | — | — | EP | claimed |
| US-20040142996-A1 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation | PORTELA & C.A., S.A. (PT) | 2004-07-22 | — | — | US | claimed |
| WO-2003097604-A9 | PYRIDINE CARBOXAMIDE DERIVATIVES AND THEIR USE AS PESTICIDES | BAYER CROPSCIENCE GMBH (DE) | 2004-05-06 | — | — | WO | claimed |
| WO-2004033447-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS PERIPHERALLY-SELECTIVE INHIBITORS OF DOPAMINE-BETA-HYDROXYLASE | PORTELA & C.A., S.A. (PT) | 2004-04-22 | — | — | WO | claimed |
| EP-1408038-A2 | Imidazole deriviatives and their use as peripherally-selective inhibitors of dopamine-beta-hydroxylase | Portela & Ca., S.A. (PT) | 2004-04-14 | — | — | EP | claimed |
| WO-2003097604-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES AND THEIR USE AS PESTICIDES | BAYER CROPSCIENCE GMBH (DE) | 2003-11-27 | — | — | WO | claimed |
| US-6420556-B1 | MULTISTAGE REACTION FOR HYPOTENSIVE AGENTS OR CARDIOTONIC AGENTS | THE PROCTER & GAMBLE COMPANY | 2002-07-16 | — | — | US | claimed |
| WO-2000035860-A2 | ACYL ISOTHIOCYANATE RESINS AND THEIR USE IN SOLID-SUPPORTED SYNTHESIS OF GUANIDINES | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142996-A1 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation | DBH, ADRB1, ADRB3 | CA1 4268/4885CA2 3544/4885ALDH1A1 492/4885 |
| US-20060166991-A1 | Pyridine carboxamide derivatives and their use as pesticides | DDT, ACHE, CYCS | CA1 1040/4885CA2 313/4885ALDH1A1 1026/4885 |
| US-20160221981-A1 | Processes for Preparing Medicaments for the Treatment of Cardiovascular Diseases and Intermediates for Use Therein | DBH, COMT, ADRB3 | CA1 3466/4885CA2 1368/4885ALDH1A1 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.