Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.33 |
| ▸ | RAD1 | O60671 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13861946 | 0.76 | L3MBTL1 (0.43) | KDM4EALDH1A1HPGDMAPK1P2RY6 | |
| SCHEMBL4373670 | 0.76 | P2RY6 (0.37) | ADRA1DKDM4EALDH1A1CYP3A4HPGD | |
| SCHEMBL6409879 | 0.75 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7572814 | 0.73 | P2RY6 (0.33) | KDM4EALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL21067362 | 0.69 | PDE4B (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6825718 | 0.69 | RAB9A (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL4365633 | 0.69 | SRC (0.41) | MAOBCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13861954 | 0.68 | TSHR (0.53) | KDM4EALDH1A1GAAPTGS2CYP2D6 | |
| SCHEMBL25221126 | 0.68 | SLC1A5 (0.38) | KDM4EALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL26099141 | 0.68 | MAPK1 (0.36) | ALDH1A1MAPK1P2RY6MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874839-B1 | FURAN- AND THIOPHENECARBOTHIOAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE REPLICATION OF HIV-1 AND HIV-1 MUTANTS | UNIROYAL CHEM CO INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-0874839-A1 | FURAN- AND THIOPHENECARBOTHIOAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE REPLICATION OF HIV-1 AND HIV-1 MUTANTS | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5696151-A | Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1997019940-A1 | FURAN- AND THIOPHENECARBOTHIOAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE REPLICATION OF HIV-1 AND HIV-1 MUTANTS | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1997-06-05 | — | — | WO | disclosed |