Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.52 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824199 | 0.90 | THRB (0.55) | THRBPTGES2PGAM1ALDH1A1PSEN1 | |
| SCHEMBL14433268 | 0.90 | THRB (0.70) | THRBPTGES2PGAM1ALDH1A1PSEN1 | |
| SCHEMBL7578661 | 0.84 | CCR2 (0.56) | THRBPTGES2PGAM1ALDH1A1PSEN1 | |
| SCHEMBL9967982 | 0.81 | MEN1 (0.62) | PTGES2ALDH1A1NFKBIARELAMCOLN3 | |
| SCHEMBL7573029 | 0.80 | PTGES2 (0.74) | THRBPTGES2PGAM1ALDH1A1NFKBIA | |
| SCHEMBL7573917 | 0.80 | MAPT (0.64) | PTGES2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7593653 | 0.80 | ALDH1A1 (0.63) | THRBPTGES2PGAM1ALDH1A1NFKBIA | |
| SCHEMBL7567353 | 0.79 | PTGES2 (0.50) | THRBPTGES2PGAM1ALDH1A1NFKBIA | |
| SCHEMBL7566450 | 0.79 | PGAM1 (0.51) | THRBPTGES2PGAM1ALDH1A1NFKBIA | |
| SCHEMBL7593138 | 0.78 | PTGES2 (0.56) | THRBPTGES2PGAM1ALDH1A1NFKBIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | claimed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | claimed |
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |