SCHEMBL7574592

SCHEMBL7574592

COC(=O)c1ccc(Cl)c(CSC)c1OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.39
ALDH1A1 P00352 5/20 0.38
TSHR P16473 2/20 0.38
KDM4E B2RXH2 4/20 0.38
HSD17B10 Q99714 1/20 0.38
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
GAA P10253 2/20 0.37
PDE4D Q08499 1/20 0.36
GALK1 P51570 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HPGD P15428 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CA12 O43570 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7572981 0.82 ABL1 (0.39) ABL1ALDH1A1TSHRKDM4EGAA
SCHEMBL7574596 0.82 POLB (0.39) ABL1ALDH1A1TSHRMEN1KMT2A
SCHEMBL7578223 0.82 ABL1 (0.41) ABL1ALDH1A1TSHRKDM4EGAA
SCHEMBL8389310 0.77 ABL1 (0.41) ABL1ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL8391842 0.75 GALK1 (0.40) ABL1ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL7577792 0.73 L3MBTL1 (0.40) ABL1ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL6852879 0.73 CA1 (0.52) ABL1ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL667011 0.73 MAPT (0.47) ALDH1A1TSHRKDM4EHSD17B10GAA
SCHEMBL8731814 0.73 ABL1 (0.44) ABL1ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL4072002 0.73 ALDH1A1 (0.50) ABL1ALDH1A1TSHRKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 EP disclosed
US-5374606-A Pre- and postemergence RHONE-POULENC AGRICULTURE LIMITED (GB) 1994-12-20 US disclosed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 EP disclosed