Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584568 | 0.90 | PKM (0.44) | PKMALDH1A1MMP13CA1CA2 | |
| SCHEMBL7575945 | 0.88 | PKM (0.54) | PKMALDH1A1MMP13CA1CA2 | |
| SCHEMBL451242 | 0.84 | MMP13 (0.44) | PKMALDH1A1MMP13CA1CA2 | |
| SCHEMBL5712580 | 0.82 | PTGS2 (0.43) | PKMALDH1A1MMP13MMP8MMP9 | |
| SCHEMBL8331507 | 0.81 | PKM (0.47) | PKMALDH1A1MMP13CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL454992 | 0.81 | PKM (0.47) | PKMMMP13CA1CA2MMP1 | |
| SCHEMBL30727537 | 0.81 | PKM (0.47) | PKMALDH1A1MMP13CA1CA2 | |
| SCHEMBL372869 | 0.81 | CA1 (0.65) | PKMALDH1A1CA1CA2GAA | |
| SCHEMBL450430 | 0.80 | PKM (0.50) | PKMALDH1A1MMP13CA1CA2 | |
| SCHEMBL450797 | 0.80 | ACHE (0.52) | PKMALDH1A1GAAFFAR4RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020196896-A1 | Exposure method, exposure apparatus, X-ray mask, semiconductor device and microstructure | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2002-12-26 | — | — | US | disclosed |
| EP-1224292-A2 | FORMYLGLYCINAMIDINRIBOTIDE SYNTHASE FROM PLANTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-24 | — | — | EP | disclosed |
| EP-1193553-A2 | Exposure method, exposure apparatus, x-ray mask, semiconductor device and microstructure | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001031025-A2 | FORMYLGLYCINAMIDINRIBOTIDE SYNTHASE FROM PLANTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-05-03 | — | — | WO | disclosed |