Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSH | P09668 | 2/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 14/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672599 | 0.82 | CTSL (0.46) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL1397920 | 0.82 | CTSL (0.46) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL707281 | 0.77 | CTSL (0.47) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL707280 | 0.77 | CTSL (0.47) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL6884054 | 0.77 | CTSL (0.47) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL24531942 | 0.73 | PEPD (0.38) | — | |
| SCHEMBL30768091 | 0.72 | CTSL (0.46) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL6856059 | 0.71 | CTSL (0.56) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL30749079 | 0.71 | CTSL (0.56) | CTSLCTSBCTSKCTSHUCHL1 | |
| SCHEMBL3259037 | 0.70 | DPP4 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143427-B2 | Method for producing aminoacetylpyrrolidinecarbonitrile derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-03-27 | — | — | US | claimed |
| EP-2123636-B1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2012-03-21 | — | — | EP | claimed |
| US-20110172444-A1 | METHOD FOR PURIFYING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND SALT THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-07-14 | — | — | US | claimed |
| EP-2332908-A1 | METHOD FOR PURIFYING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND SALT THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2011-06-15 | — | — | EP | claimed |
| US-20100099892-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUTICAL CO. LTD | 2010-04-22 | — | — | US | claimed |
| EP-2123636-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | claimed |
| CN-118234720-A | Radiolabeled fibroblast activation protein ligand | 菲罗化学股份公司 | 2024-06-21 | — | — | CN | disclosed |
| US-20240148916-A1 | BIVALENT FIBROBLAST ACTIVATION PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS | PHILOCHEM AG (CH) | 2024-05-09 | — | — | US | disclosed |
| EP-4291554-A1 | BIVALENT FIBROBLAST ACTIVATION PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS | Philochem AG (CH) | 2023-12-20 | — | — | EP | disclosed |
| CN-116917278-A | Divalent fibroblast activation protein ligands for targeted delivery applications | 菲罗化学股份公司 | 2023-10-20 | — | — | CN | disclosed |
| WO-2023144379-A1 | HIGH-AFFINITY LIGANDS OF FIBROBLAST ACTIVATION PROTEIN FOR TARGETED DELIVERY APPLICATIONS | PHILOCHEM AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| US-20230147962-A1 | FIBROBLAST ACTIVATION PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS | PHILOCHEM AG (CH) | 2023-05-11 | — | — | US | disclosed |
| WO-2023057457-A1 | RADIOLABELLED FIBROBLAST ACTIVATION PROTEIN LIGANDS | PHILOCHEM AG (CH) | 2023-04-13 | — | — | WO | disclosed |
| JP-2009114127-A | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUT CO LTD | 2009-05-28 | — | — | JP | disclosed |
| CN-101395131-A | Method for producing aminoacetylpyrrolidinecarbonitrile derivative and production intermediate thereof | KYORIN SEIYAKU KK (JP) | 2009-03-25 | — | — | CN | disclosed |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1995237-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2008-11-26 | — | — | EP | disclosed |
| JP-2008239543-A | METHOD FOR PRODUCING BICYCLO-AMINOACETYL-PYRROLIDINE-CARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF | KYORIN PHARMACEUT CO LTD | 2008-10-09 | — | — | JP | disclosed |
| WO-2008114857-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-09-25 | — | — | WO | disclosed |
| WO-2007102286-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099892-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | DPP4, DPP7, DPP8 | CTSL 150/4885CTSB 782/4885CTSK 743/4885 |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | CBR3, CPS1, CBR1 | CTSL 2238/4885CTSB 1611/4885CTSK 2617/4885 |
| US-20230147962-A1 | FIBROBLAST ACTIVATION PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS | FAP, FIBP, FGFR1 | CTSL 272/4885CTSB 109/4885CTSK 321/4885 |
| US-20240148916-A1 | BIVALENT FIBROBLAST ACTIVATION PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS | FAP, FIBP, FGFR2 | CTSL 750/4885CTSB 164/4885CTSK 734/4885 |
| US-20110172444-A1 | METHOD FOR PURIFYING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND SALT THEREOF | DPP4, DPP7, DPP9 | CTSL 722/4885CTSB 1537/4885CTSK 2246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.